A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Daipayan Banerjee; Kurt Langberg; Salar Abbas; Eric Odermatt; Praveen Yerramothu; Martin Volaric; Matthew A. Reidenbach; Kathy J. Krentz; C. Dustin Rubinstein; David L. Brautigan; Tarek Abbas; Bradley D. Gelfand; Jayakrishna Ambati; Nagaraj Kerur

doi:10.1038/s41467-021-26240-9

Nature Communications (Oct 2021)

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Daipayan Banerjee,
Kurt Langberg,
Salar Abbas,
Eric Odermatt,
Praveen Yerramothu,
Martin Volaric,
Matthew A. Reidenbach,
Kathy J. Krentz,
C. Dustin Rubinstein,
David L. Brautigan,
Tarek Abbas,
Bradley D. Gelfand,
Jayakrishna Ambati,
Nagaraj Kerur

Affiliations

Daipayan Banerjee: Aravind Medical Research Foundation
Kurt Langberg: Center for Advanced Vision Science, University of Virginia School of Medicine
Salar Abbas: Center for Advanced Vision Science, University of Virginia School of Medicine
Eric Odermatt: Center for Advanced Vision Science, University of Virginia School of Medicine
Praveen Yerramothu: Center for Advanced Vision Science, University of Virginia School of Medicine
Martin Volaric: Department of Environmental Sciences, University of Virginia
Matthew A. Reidenbach: Department of Environmental Sciences, University of Virginia
Kathy J. Krentz: Genome Editing & Animal Models Core, University of Wisconsin Biotechnology Center
C. Dustin Rubinstein: Genome Editing & Animal Models Core, University of Wisconsin Biotechnology Center
David L. Brautigan: Center for Cell Signaling, University of Virginia School of Medicine
Tarek Abbas: Department of Radiation Oncology, University of Virginia
Bradley D. Gelfand: Center for Advanced Vision Science, University of Virginia School of Medicine
Jayakrishna Ambati: Center for Advanced Vision Science, University of Virginia School of Medicine
Nagaraj Kerur: Center for Advanced Vision Science, University of Virginia School of Medicine

DOI: https://doi.org/10.1038/s41467-021-26240-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 24

Abstract

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Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair pathway, while simultaneously suppressing the homology-directed repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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