Nature Communications (Oct 2021)

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

  • Daipayan Banerjee,
  • Kurt Langberg,
  • Salar Abbas,
  • Eric Odermatt,
  • Praveen Yerramothu,
  • Martin Volaric,
  • Matthew A. Reidenbach,
  • Kathy J. Krentz,
  • C. Dustin Rubinstein,
  • David L. Brautigan,
  • Tarek Abbas,
  • Bradley D. Gelfand,
  • Jayakrishna Ambati,
  • Nagaraj Kerur

DOI
https://doi.org/10.1038/s41467-021-26240-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 24

Abstract

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Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair pathway, while simultaneously suppressing the homology-directed repair.