A High De Ritis Ratio is Associated with Mortality in Adult Trauma Patients

Abstract

Ching-Hua Tsai, Ting-Min Hsieh, Shiun-Yuan Hsu, Ching-Hua Hsieh Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83301, TaiwanCorrespondence: Ching-Hua Hsieh, Tel [phone], Email [email protected]: The De Ritis ratio, which is the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT), has been suggested as a potential prognostic marker for various diseases. This study aimed to investigate the association between the De Ritis ratio and in-hospital mortality in adult trauma patients.Methods: A total of 17,472 adult trauma patients hospitalized between January 1, 2009, and December 31, 2020, were allocated into groups according to the De Ritis ratio. The normal range of the De Ritis ratio was calculated from 3320 individuals in the National Taiwan Biobank. Statistical analyses were performed using SPSS software.Results: Patients with a De Ritis ratio > 1.6 had a significantly higher in-hospital mortality rate (7.3% vs 1.5%, odds ratio 5.29; Q1–Q3 2.72– 10.30; p 1.6 may serve as an early prognostic tool to identify adult trauma patients at high risk of in-hospital mortality.Keywords: aspartate aminotransferase, AST, alanine aminotransferase, ALT, De Ritis ratio, in-hospital mortality, trauma

Keywords

• aspartate aminotransferase (ast)
• alanine aminotransferase (alt)
• de ritis ratio
• in-hospital mortality
• trauma