Viruses (Dec 2015)

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

  • Samantha Turnbull,
  • Emma J. West,
  • Karen J. Scott,
  • Elizabeth Appleton,
  • Alan Melcher,
  • Christy Ralph

DOI
https://doi.org/10.3390/v7122938
Journal volume & issue
Vol. 7, no. 12
pp. 6291 – 6312

Abstract

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The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold.

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