ZONEGRAN. NEW IN EVIDENTIAL PHARMACOTHERAPY OF EPILEPSY: OPPORTUNITIES AND EXPECTATIONS

Abstract

Abstract: this article represents review of literature devoted to a new antiepileptic drug Zonegran (zonisamide, ZNS). History of successful clinical use of ZNS in world practice lasts for 25 years. Zonisamide is on the Russian market from 2014 and is approved for monotherapy and adjunctive therapy of partial seizures with or without secondary generalization. This review is based on principles of evidence based medicine. Data of ZNS mechanism of action and pharmacokinetics are considered. Results of the most significant studies of ZNS efficacy and tolerability in drug-resistant focal epilepsy in adults and children in adjunctive and monotherapy regimes are presented. Possibilities of clinical use of ZNS in treatment of concomitant diseases are considered.

Keywords

• epilepsy
• zonisamide
• efficacy
• tolerability