Nature Communications (Aug 2022)
Molecular characterization of colorectal cancer related peritoneal metastatic disease
- Kristiaan J. Lenos,
- Sander Bach,
- Leandro Ferreira Moreno,
- Sanne ten Hoorn,
- Nina R. Sluiter,
- Sanne Bootsma,
- Felipe A. Vieira Braga,
- Lisanne E. Nijman,
- Tom van den Bosch,
- Daniel M. Miedema,
- Erik van Dijk,
- Bauke Ylstra,
- Ruth Kulicke,
- Fred P. Davis,
- Nicolas Stransky,
- Gromoslaw A. Smolen,
- Robert R. J. Coebergh van den Braak,
- Jan N. M. IJzermans,
- John W. M. Martens,
- Sally Hallam,
- Andrew D. Beggs,
- Geert J. P. L. Kops,
- Nico Lansu,
- Vivian P. Bastiaenen,
- Charlotte E. L. Klaver,
- Maria C. Lecca,
- Khalid El Makrini,
- Clara C. Elbers,
- Mark P. G. Dings,
- Carel J. M. van Noesel,
- Onno Kranenburg,
- Jan Paul Medema,
- Jan Koster,
- Lianne Koens,
- Cornelis J. A. Punt,
- Pieter J. Tanis,
- Ignace H. de Hingh,
- Maarten F. Bijlsma,
- Jurriaan B. Tuynman,
- Louis Vermeulen
Affiliations
- Kristiaan J. Lenos
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Sander Bach
- Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Leandro Ferreira Moreno
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Sanne ten Hoorn
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Nina R. Sluiter
- Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Sanne Bootsma
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Felipe A. Vieira Braga
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Lisanne E. Nijman
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Tom van den Bosch
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Daniel M. Miedema
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Erik van Dijk
- Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam
- Bauke Ylstra
- Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam
- Ruth Kulicke
- Celsius Therapeutics
- Fred P. Davis
- Celsius Therapeutics
- Nicolas Stransky
- Celsius Therapeutics
- Gromoslaw A. Smolen
- Celsius Therapeutics
- Robert R. J. Coebergh van den Braak
- Department of Surgery, Erasmus MC University Medical Center
- Jan N. M. IJzermans
- Department of Surgery, Erasmus MC University Medical Center
- John W. M. Martens
- Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus MC University Medical Center, Rotterdam, the Netherlands & Cancer Genomics Center
- Sally Hallam
- Surgical Research Laboratory, Institute of Cancer and Genomic Science, University of Birmingham
- Andrew D. Beggs
- Surgical Research Laboratory, Institute of Cancer and Genomic Science, University of Birmingham
- Geert J. P. L. Kops
- Oncode Institute
- Nico Lansu
- Oncode Institute
- Vivian P. Bastiaenen
- Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Charlotte E. L. Klaver
- Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Maria C. Lecca
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Khalid El Makrini
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Clara C. Elbers
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Mark P. G. Dings
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Carel J. M. van Noesel
- Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam
- Onno Kranenburg
- Department of Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht
- Jan Paul Medema
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Jan Koster
- Amsterdam UMC location University of Amsterdam, Department of Oncogenomics, Meibergdreef 9
- Lianne Koens
- Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam
- Cornelis J. A. Punt
- Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University
- Pieter J. Tanis
- Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Ignace H. de Hingh
- Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW - School for Oncology and Developmental Biology, Maastricht University
- Maarten F. Bijlsma
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- Jurriaan B. Tuynman
- Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Louis Vermeulen
- Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
- DOI
- https://doi.org/10.1038/s41467-022-32198-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.
