Marine Drugs (Sep 2019)

Update on Monoterpenes from Red Macroalgae: Isolation, Analysis, and Bioactivity

  • Ana-Marija Cikoš,
  • Mladenka Jurin,
  • Rozelindra Čož-Rakovac,
  • Stela Jokić,
  • Igor Jerković

DOI
https://doi.org/10.3390/md17090537
Journal volume & issue
Vol. 17, no. 9
p. 537

Abstract

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Macroalgae produce a wide range of monoterpenes as secondary metabolites of mevalonate (MVA) and/or methylerythritol phosphate (MEP) pathway (often including haloperoxidase action). Great biodiversity of macroalgal monoterpenes was reported including acyclic, monocyclic, and bicyclic structures. Halogenated monoterpenes exhibited significant biological activity (e.g., anticancer, antiplasmodial, and insecticidal) that is influenced by the number of present halogens (higher halogen content is preferable, especially bromine) and their position within the monoterpene skeleton. In distinction from the existing reviews, the present review provides novelty with respect to: (a) exclusively monoterpenes from red macroalgae are targeted; (b) biosynthesis, isolation, and analysis, as well as bioactivity of monoterpenes are represented; (c) the methods of their isolation, analysis, and structure elucidation are summarized; (d) the bioactivity of macroalgal monoterpenes is systematically presented with emphasis on anticancer activity; (e) the literature references were updated.

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