An operationally simple, fast and green synthesis of novel γ-hydroxyphosphonate and phosphine oxide derivatives

Abstract

A green and versatile method for the preparation of γ-hydroxyphosphonate and phosphine oxide derivatives in 5 min, is accomplished through the reduction of γ-phosphonylketones with sodium borohydride supported on alumina, at room temperature, under solvent free conditions.

Keywords

• γ-hydroxyphosphonates
• reduction
• fast synthesis
• green synthesis
• solid-supported synthesis