Strategy of control for bacterial biofilm processes

Abstract

Main directions of the modern search of the antibiofilm preparations aimed at adhesive bacterial reactions, control of QS-systems, influence over bis-(3’-5’)-cyclic dimeric guanosine monophosphate (cdi-GMP), and secretory bacterial processes are analysed. Approaches for biofilm dispersal and increasing the sensitivity of biofilm bacteria to antimicrobial drugs are discussed. It is underlined that the majority of inhibitor molecules were studied in vitro or in infected mice experiments. It is prognosed that in future there will appear medical preparations which will help for fighting bacterial biofilms preventing their development and spreading in the host organism.

Keywords

• биопленки
• бактерии
• адгезия
• секреция
• регуляция
• отторжение