Immunotherapeutic Challenges for Pediatric Cancers

Brian Hutzen; Mohammed Ghonime; Joel Lee; Elaine R. Mardis; Ruoning Wang; Dean A. Lee; Mitchell S. Cairo; Ryan D. Roberts; Timothy P. Cripe; Kevin A. Cassady

Molecular Therapy: Oncolytics (Dec 2019)

Immunotherapeutic Challenges for Pediatric Cancers

Brian Hutzen,
Mohammed Ghonime,
Joel Lee,
Elaine R. Mardis,
Ruoning Wang,
Dean A. Lee,
Mitchell S. Cairo,
Ryan D. Roberts,
Timothy P. Cripe,
Kevin A. Cassady

Affiliations

Brian Hutzen: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA
Mohammed Ghonime: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA
Joel Lee: The Ohio State University, Columbus, OH, USA
Elaine R. Mardis: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA; Institute for Genomic Medicine, The Ohio State University College of Medicine, Columbus, OH, USA
Ruoning Wang: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Dean A. Lee: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Mitchell S. Cairo: Department of Pediatrics, Cancer and Blood Diseases Center, New York Medical College, Valhalla, NY, USA
Ryan D. Roberts: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Timothy P. Cripe: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Kevin A. Cassady: The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA; Division of Pediatric Infection Diseases, New York Medical College, Valhalla, NY, USA; Corresponding author: Kevin A. Cassady, MD, The Research Institute at Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, 700 Children’s Drive, Columbus, OH 43205, USA.

Journal volume & issue: Vol. 15
pp. 38 – 48

Abstract

Read online

Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers share some similarities related to microenvironmental changes, pediatric cancers are unique, and adult cancer practices may not be wholly applicable to our pediatric patients. This review highlights the differences in tumorigenesis, viral infection, and immunologic response between children and adults that need to be considered when trying to apply experiences from experimental therapies in adult cancer patients to pediatric cancers. Keywords: natural killer cells, CAR T cells, oncolytic virotherapy, sarcoma, brain tumor, immunotherapy, metabolic antagonism, dendritic cell vaccine, immunosuppression, neo-antigen

Published in Molecular Therapy: Oncolytics

ISSN: 2372-7705 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.cell.com/molecular-therapy-family/oncolytics/latest-content

About the journal