IMMUNE RESPONSE IN DECOMPENSATED CHRONIC HEART FAILURE OF ISCHEMIC ORIGIN

Abstract

Recently, a significance has been established, for the role of inflammation in the pathology of chronic heart failure (CHF). It is well known that raised level of circulating pro-inflammatory cytokines in ischemic CHF patients correlate with the severity and prognosis of the disease. Monocytes play key role in an inflammatory cascade and are the main source of pro-, as contra-inflammatory cytokines. Disbalance of physiological inflammation in alteration and healing of the myocardium might lead to formation of pathological chronic inflammation. In the article, the role of monocytes discussed, and of inflammation, in CHF and its decompensation. The kinds of cytokines observed with their role in inflammation. Also, the analysis presented, of the drugs used for modulation of immune response in CHF.

Keywords

• acute decompensation of chronic heart failure
• macrophages
• cytokines
• innate immunity
• adaptive immunity