A decade's worth of impact: Dox loaded liposomes in anticancer activity

Puja Ghosh; Himja Tiwari; Jaya Lakkakula; Arpita Roy; Talha Bin Emran; Summya Rashid; Saad Alghamdi; Bodour S. Rajab; Mazen Almehmadi; Mamdouh Allahyani; Abdulelah Aljuaid; Ahad Amer Alsaiari; Rohit Sharma; Ahmad O. Babalghith

Materials Today Advances (Dec 2022)

A decade's worth of impact: Dox loaded liposomes in anticancer activity

Puja Ghosh,
Himja Tiwari,
Jaya Lakkakula,
Arpita Roy,
Talha Bin Emran,
Summya Rashid,
Saad Alghamdi,
Bodour S. Rajab,
Mazen Almehmadi,
Mamdouh Allahyani,
Abdulelah Aljuaid,
Ahad Amer Alsaiari,
Rohit Sharma,
Ahmad O. Babalghith

Affiliations

Puja Ghosh: Pondicherry University, Chinna Kalapet, Kalapet, Puducherry, 605014, India
Himja Tiwari: Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India
Jaya Lakkakula: Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India; Centre for Computational Biology and Translational Research, Amity Institute of Biotechnology, Amity University, Mumbai, Maharashtra, 410206, India; Corresponding author. Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India.
Arpita Roy: Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India; Corresponding author. Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India.
Talha Bin Emran: Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh
Summya Rashid: Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Saudi Arabia
Saad Alghamdi: Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
Bodour S. Rajab: Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
Mazen Almehmadi: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
Mamdouh Allahyani: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
Abdulelah Aljuaid: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
Ahad Amer Alsaiari: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
Rohit Sharma: Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India; Corresponding author. Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Ahmad O. Babalghith: Medical Genetics Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

Journal volume & issue: Vol. 16
p. 100313

Abstract

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Clinically approved therapeutics associated with cancer are limited to mostly chemotherapy, surgery and radiotherapy in spite of the advancements in the biomedical field. Due to the cardiotoxicity and uncountable side effects brought by the prevailing treatment strategies, demands are growing for targeted drug delivery using nanomaterials. For this the most commonly used drug, doxorubicin (DOX) is encapsulated within several type of nanovesicles to observe their anticancer activity. Among them, DOX encapsulated liposomes gained popularity because of their clinical success and lower toxicity. To enhance their efficiency and site specific delivery, attempts are made to modify the liposomes by combining them with peptides, aptamers, antibodies etc to develop pH, thermal, UV-sensitive and electro-magnetic liposomal nanocarriers for controlled drug release. The novel strategies for the treatment of Breast, Lung, Liver, Pancreatic, Prostate, Ovarian, Cervical, Blood, Brain and Colon cancer using modified liposomes encapsulating DOX are illustrated in this review.

Published in Materials Today Advances

ISSN: 2590-0498 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-today-advances

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