Communications Biology (Dec 2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
- Gunn A. Hildrestrand,
- Veslemøy Rolseth,
- Nicolas Kunath,
- Rajikala Suganthan,
- Vidar Jensen,
- Anna M. Bugaj,
- Marion S. Fernandez-Berrocal,
- Sunniva B. Sikko,
- Susanne Vetlesen,
- Anna Kuśnierczyk,
- Ann-Karin Olsen,
- Kristine B. Gützkow,
- Alexander D. Rowe,
- Wei Wang,
- Olve Moldestad,
- Monica D. Syrstad,
- Geir Slupphaug,
- Lars Eide,
- Arne Klungland,
- Pål Sætrom,
- Luisa Luna,
- Jing Ye,
- Katja Scheffler,
- Magnar Bjørås
Affiliations
- Gunn A. Hildrestrand
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Veslemøy Rolseth
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Nicolas Kunath
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Rajikala Suganthan
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Vidar Jensen
- GliaLab, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Anna M. Bugaj
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Marion S. Fernandez-Berrocal
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Sunniva B. Sikko
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Susanne Vetlesen
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Anna Kuśnierczyk
- Proteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology
- Ann-Karin Olsen
- Department of Molecular Biology, National Institute of Public Health
- Kristine B. Gützkow
- Department of Molecular Biology, National Institute of Public Health
- Alexander D. Rowe
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Wei Wang
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Olve Moldestad
- Laboratory of Cellular Neurophysiology and Ion Channel Function, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
- Monica D. Syrstad
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Geir Slupphaug
- Proteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology
- Lars Eide
- Department of Medical Biochemistry, Oslo University Hospital and University of Oslo
- Arne Klungland
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Pål Sætrom
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Luisa Luna
- Department of Microbiology, Oslo University Hospital and University of Oslo
- Jing Ye
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Katja Scheffler
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
- Magnar Bjørås
- Department of Microbiology, Oslo University Hospital and University of Oslo
- DOI
- https://doi.org/10.1038/s42003-021-02864-x
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair. Their results suggest that loss of both NEIL1 and NEIL2 dysregulates genes relevant to synaptic function and modulates behavior in mice.
