Hodgkin's variant of Richter transformation during ibrutinib therapy: A case report and review of the literature

Abstract

Abstract Hodgkin's variant of Richter transformation is a rare complication of chronic lymphocytic leukemia and is associated with inferior outcomes compared to de novo Hodgkin lymphoma. Further data concerning prognosis and treatment of Hodgkin's variant of Richter transformation occurring in the setting of novel targeted therapies are needed.

Keywords

• chronic lymphocytic leukemia
• Hodgkin lymphoma
• ibrutinib
• Richter transformation