Frontiers in Pediatrics (Jul 2020)
High Frequency of Fusion Gene Transcript Resulting From t(10;11)(p12;q23) Translocation in Pediatric Acute Myeloid Leukemia in Poland
- Teofila Ksiazek,
- Teofila Ksiazek,
- Malgorzata Czogala,
- Malgorzata Czogala,
- Przemyslaw Kaczowka,
- Przemyslaw Kaczowka,
- Beata Sadowska,
- Katarzyna Pawinska-Wasikowska,
- Katarzyna Pawinska-Wasikowska,
- Mirosław Bik-Multanowski,
- Barbara Sikorska-Fic,
- Michał Matysiak,
- Jolanta Skalska-Sadowska,
- Jacek Wachowiak,
- Anna Rodziewicz-Konarska,
- Alicja Chybicka,
- Katarzyna Muszynska-Rosłan,
- Maryna Krawczuk-Rybak,
- Dominik Grabowski,
- Jerzy Kowalczyk,
- Lucyna Maciejka-Kemblowska,
- Elzbieta Adamkiewicz-Drozynska,
- Wojciech Mlynarski,
- Renata Tomaszewska,
- Tomasz Szczepanski,
- Joanna Pohorecka,
- Grazyna Karolczyk,
- Agnieszka Mizia-Malarz,
- Katarzyna Mycko,
- Wanda Badowska,
- Karolina Zielezinska,
- Tomasz Urasinski,
- Irena Karpinska-Derda,
- Mariola Woszczyk,
- Małgorzata Ciebiera,
- Monika Lejman,
- Szymon Skoczen,
- Szymon Skoczen,
- Walentyna Balwierz,
- Walentyna Balwierz
Affiliations
- Teofila Ksiazek
- Department of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Teofila Ksiazek
- Department of Pediatric Oncology and Hematology, Cytogenetics and Molecular Genetics Laboratory, University Children's Hospital, Kraków, Poland
- Malgorzata Czogala
- Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Malgorzata Czogala
- University Children's Hospital, Kraków, Poland
- Przemyslaw Kaczowka
- Department of Pediatric Oncology and Hematology, Cytogenetics and Molecular Genetics Laboratory, University Children's Hospital, Kraków, Poland
- Przemyslaw Kaczowka
- Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Beata Sadowska
- Department of Pediatric Oncology and Hematology, Cytogenetics and Molecular Genetics Laboratory, University Children's Hospital, Kraków, Poland
- Katarzyna Pawinska-Wasikowska
- Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Katarzyna Pawinska-Wasikowska
- University Children's Hospital, Kraków, Poland
- Mirosław Bik-Multanowski
- Department of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Barbara Sikorska-Fic
- Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland
- Michał Matysiak
- Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland
- Jolanta Skalska-Sadowska
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznań, Poland
- Jacek Wachowiak
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznań, Poland
- Anna Rodziewicz-Konarska
- Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Medical University of Wroclaw, Wrocław, Poland
- Alicja Chybicka
- Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Medical University of Wroclaw, Wrocław, Poland
- Katarzyna Muszynska-Rosłan
- Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland
- Maryna Krawczuk-Rybak
- Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland
- Dominik Grabowski
- Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland
- Jerzy Kowalczyk
- Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland
- Lucyna Maciejka-Kemblowska
- 0Department of Pediatrics, Hematology and Oncology, University Medical Centre, Gdańsk, Poland
- Elzbieta Adamkiewicz-Drozynska
- 0Department of Pediatrics, Hematology and Oncology, University Medical Centre, Gdańsk, Poland
- Wojciech Mlynarski
- 1Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Łódź, Poland
- Renata Tomaszewska
- 2Department of Pediatrics Hematology and Oncology, Medical University of Silesia, Zabrze, Poland
- Tomasz Szczepanski
- 2Department of Pediatrics Hematology and Oncology, Medical University of Silesia, Zabrze, Poland
- Joanna Pohorecka
- 3Pediatric Department of Hematology and Oncology, Regional Polyclinic Hospital in Kielce, Kielce, Poland
- Grazyna Karolczyk
- 3Pediatric Department of Hematology and Oncology, Regional Polyclinic Hospital in Kielce, Kielce, Poland
- Agnieszka Mizia-Malarz
- 4Department of Oncology, Hematology and Chemotherapy, John Paul II Upper Silesian Child Heath Centre, The Independent Public Clinical Hospital No. 6 of the Medical University of Silesia in Katowice, Katowice, Poland
- Katarzyna Mycko
- 5Department of Pediatrics and Hematology and Oncology, Province Children's Hospital, Olsztyn, Poland
- Wanda Badowska
- 5Department of Pediatrics and Hematology and Oncology, Province Children's Hospital, Olsztyn, Poland
- Karolina Zielezinska
- 6Department of Pediatrics, Hematology and Oncology, Pomeranian Medical University, Szczecin, Poland
- Tomasz Urasinski
- 6Department of Pediatrics, Hematology and Oncology, Pomeranian Medical University, Szczecin, Poland
- Irena Karpinska-Derda
- 7Department of Pediatrics, Hematology and Oncology, City Hospital, Chorzow, Poland
- Mariola Woszczyk
- 7Department of Pediatrics, Hematology and Oncology, City Hospital, Chorzow, Poland
- Małgorzata Ciebiera
- 8Department of Pediatric Oncohematology, Clinical Province Hospital of Rzeszów, Rzeszow, Poland
- Monika Lejman
- 9Department of Genetic Diagnostics, II Department Pediatrics, Medical University of Lublin, Lublin, Poland
- Szymon Skoczen
- Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Szymon Skoczen
- University Children's Hospital, Kraków, Poland
- Walentyna Balwierz
- Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- Walentyna Balwierz
- University Children's Hospital, Kraków, Poland
- DOI
- https://doi.org/10.3389/fped.2020.00278
- Journal volume & issue
-
Vol. 8
Abstract
11q23/MLL rearrangements are frequently detected in pediatric acute myeloid leukemia. The analysis of their clinical significance is difficult because of the multitude of translocation fusion partners and their low frequency. The presence of t(10;11)(p12;q23) translocation was previously identified in pediatric acute myelogenous leukemia (AML). It is considered as the second most common translocation detected in pediatric 11q23/MLL-rearranged (present KMT2A) AML, after t(9;11)(p22;q23). The presence of the above translocation was previously identified as an unfavorable prognostic factor. Since June 2015, the Polish Pediatric Leukemia/Lymphoma Study Group has applied the therapeutic protocol requiring extensive diagnostics of genetic changes in pediatric AML. Until November 2019, molecular genetic studies were performed in 195 children with diagnosed AML to identify carriers of fusion gene transcripts for 28 most common chromosomal translocations in acute leukemia. The fusion gene transcript for translocation t(10;11)(p12;q23) involving MLL gene was detected with unexpectedly high frequency (8.9%) in our research. It was the highest frequency of all detected MLL rearrangements, as well as other detected fusion gene transcripts from chromosomal aberrations characteristic for AML. It seems that chromosomal aberration between chromosomes 10 and 11 can be relatively frequent in some populations. Paying attention to this fact and ensuring proper genetic diagnosis seem to be important for appropriate allocation of patients to risk groups of pediatric AML treatment protocols.
Keywords
- acute myeloid leukemia
- 11q23/KMT2A rearrangements
- MLL rearrangements
- children
- risk stratification
- treatment results
