Sodium butyrate impedes the lymphoma caused by Marek’s disease virus via regulating the mitochondrial apoptosis pathway

Qiaoer Lin; Jun Zhou; Fan Yang; Congsen Zheng; Meiting Chen; Chuanzhe Chang; Shikai Cai; Feng Wen; Feng Wen; Nina Wang; Nina Wang; Yanfeng Chen; Yanfeng Chen; Limei Qin; Limei Qin

doi:10.3389/fvets.2024.1360878

Frontiers in Veterinary Science (Feb 2024)

Sodium butyrate impedes the lymphoma caused by Marek’s disease virus via regulating the mitochondrial apoptosis pathway

Qiaoer Lin,
Jun Zhou,
Fan Yang,
Congsen Zheng,
Meiting Chen,
Chuanzhe Chang,
Shikai Cai,
Feng Wen,
Feng Wen,
Nina Wang,
Nina Wang,
Yanfeng Chen,
Yanfeng Chen,
Limei Qin,
Limei Qin

Affiliations

Qiaoer Lin: School of Life Science and Engineering, Foshan University, Foshan, China
Jun Zhou: School of Life Science and Engineering, Foshan University, Foshan, China
Fan Yang: School of Life Science and Engineering, Foshan University, Foshan, China
Congsen Zheng: School of Life Science and Engineering, Foshan University, Foshan, China
Meiting Chen: School of Life Science and Engineering, Foshan University, Foshan, China
Chuanzhe Chang: School of Life Science and Engineering, Foshan University, Foshan, China
Shikai Cai: School of Life Science and Engineering, Foshan University, Foshan, China
Feng Wen: School of Life Science and Engineering, Foshan University, Foshan, China
Feng Wen: Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, China
Nina Wang: School of Life Science and Engineering, Foshan University, Foshan, China
Nina Wang: Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, China
Yanfeng Chen: School of Life Science and Engineering, Foshan University, Foshan, China
Yanfeng Chen: Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, China
Limei Qin: School of Life Science and Engineering, Foshan University, Foshan, China
Limei Qin: Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, China

DOI: https://doi.org/10.3389/fvets.2024.1360878
Journal volume & issue: Vol. 11

Abstract

Read online

Sodium butyrate (NaB) has garnered attention in recent years for its ability to impede the malignant progression of tumors. In order to explore the potential inhibitory effects of NaB on the replication of Marek’s disease virus (MDV) and subsequent lymphoma formation, newly hatched chickens were infected with the vvMDV Md5 strain and administered NaB prior to (prevention group) or following (treatment group) Md5 inoculation. The results revealed that NaB played a pivotal role in diminishing both the incidence and fatality rates in chickens afflicted with Md5 infection. Notably, NaB exhibited a remarkable capacity to inhibit the expression of MDV immediate early genes, i.e., ICP4 and ICP27, thus attenuating tumorigenesis in the chicken spleen. To further elucidate the mechanism of NaB on lymphoma cells, MDV bearing lymphoma cells, i.e., MSB-1 were exposed to NaB for 24 h prior to various experimental tests. The results revealed that NaB effectively hindered the proliferation, migration, and colony formation of MSB-1 cells. Furthermore, NaB demonstrated the ability to modulate the key molecules in mitochondrial apoptosis pathway. Taken together, these findings reveal that NaB can impede the lymphoma caused by MDV via regulating the mitochondrial apoptosis pathway, both in vitro and in vivo. These results suggest that the utilization of NaB warrants serious consideration as a promising approach for the prevention of MDV.

Published in Frontiers in Veterinary Science

ISSN: 2297-1769 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://www.frontiersin.org/journals/veterinary-science

About the journal

Abstract

Keywords