Beilstein Journal of Organic Chemistry (Mar 2009)

N-acylation of ethanolamine using lipase: a chemoselective catalyst

  • Mazaahir Kidwai,
  • Roona Poddar,
  • Poonam Mothsra

DOI
https://doi.org/10.3762/bjoc.5.10
Journal volume & issue
Vol. 5, no. 1
p. 10

Abstract

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The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.

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