A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

Wenchao Qu; Bao Hu; John W. Babich; Nicole Waterhouse; Marybeth Dooley; Shashikanth Ponnala; Julie Urgiles

doi:10.1038/s41467-020-15556-7

Nature Communications (Apr 2020)

A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

Wenchao Qu,
Bao Hu,
John W. Babich,
Nicole Waterhouse,
Marybeth Dooley,
Shashikanth Ponnala,
Julie Urgiles

Affiliations

Wenchao Qu: Citigroup Biomedical Imaging Center, Weill Cornell Medicine
Bao Hu: Citigroup Biomedical Imaging Center, Weill Cornell Medicine
John W. Babich: Citigroup Biomedical Imaging Center, Weill Cornell Medicine
Nicole Waterhouse: Citigroup Biomedical Imaging Center, Weill Cornell Medicine
Marybeth Dooley: Citigroup Biomedical Imaging Center, Weill Cornell Medicine
Shashikanth Ponnala: Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine
Julie Urgiles: Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine

DOI: https://doi.org/10.1038/s41467-020-15556-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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