The Effect of Glucose-Insulin-Potassium (GIK) Administration on Clinical Outcomes after Pediatric Cardiac Surgeries with Cardiopulmonary Bypass: A Single-Blind Clinical Trial

Abstract

Background: With more than 40 years of research on the effects of glucose-insulin-potassium (GIK) solution on the clinical consequences of heart surgery, its use and impact are still challenging, Therefore, the aim of this study was to investigate the effect of GIK solution on clinical outcomes after pediatric heart surgeries with cardiopulmonary bypass. Methods: This clinical trial study was performed on 49 patients undergoing cardiac surgery by using cardiopulmonary bypass in children aged younger than 12 years in Shahid Chamran hospital, Isfahan, Iran. Patients were divided into two groups of GIK (25 people) and control (24 people). The GIK group received GIK solution, and the control group received normal saline solution. Arrhythmia, the frequency of taking insulin and adrenaline drugs, the need for cardiac shock, hospitalization and intensive care unit (ICU) time, and blood pressure were recorded in both groups. Data were analyzed using independent t, chi-square, and repeated measures ANOVA tests. Findings: The use of GIK solution significantly reduced the need for postoperative shock, the frequency of arrhythmia, duration of hospitalization, and the amount of inotrope drugs in comparison with the control group (P < 0.05). Conclusion: According to the results of the study, the use of GIK solution during cardiac surgery can reduce clinical outcomes such as hospitalization and ICU time, the need for cardiac shock, and arrhythmia after open-heart surgery in pediatric patients.

Keywords

• glucose
• insulin
• potassium
• heart surgery
• pediatrics
• cardiopulmonary bypass