Pharmacogenetics and Inflammatory Bowel Diseases in Adults and Children: Diagnosis and Treatment Prospects

Abstract

The article highlights modern concepts of inflammatory diseases in adults and children in terms of genetic possibilities for diagnosing Crohn's disease and ulcerative colitis. It names the main candidate genes, which, in the presence of their specific polymorphisms, indicate the occurrence of a high risk of inflammatory bowel disease. The principles of modern therapy, the possibilities of pharma-cogenetic testing in predicting the effectiveness or risks of reducing the safety of drug therapy are described. The article focuses on modern trends and perspectives in ulcerative colitis and Crohn's disease treatment.

Keywords

• inflammatory bowel disease
• ulcerative colitis
• crohn's disease
• pharmacogenetics
• polymorphisms
• 5-asa
• mesalazine
• immunomodulators
• glucocorticosteroids
• monoclonal antibodies
• 5-аск