E-Journal of Chemistry (Jan 2012)

Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles

  • Mona A. Hosny,
  • Hyam A. Radwan,
  • Emtithal A. El-Sawi

DOI
https://doi.org/10.1155/2012/365647
Journal volume & issue
Vol. 9, no. 4
pp. 1737 – 1745

Abstract

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Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). The latter compounds were evaluated for their antimicrobial and anticancer activities. The newly synthesized compounds were characterized by IR, 1HNMR and mass spectra.