Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Pei Liu; Changpeng Chen; Xuefeng Cong; Jinghua Tang; Xiaoming Zeng

doi:10.1038/s41467-018-07069-1

Nature Communications (Nov 2018)

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Pei Liu,
Changpeng Chen,
Xuefeng Cong,
Jinghua Tang,
Xiaoming Zeng

Affiliations

Pei Liu: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University
Changpeng Chen: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University
Xuefeng Cong: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University
Jinghua Tang: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University
Xiaoming Zeng: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University

DOI: https://doi.org/10.1038/s41467-018-07069-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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