iScience (Mar 2021)
Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors
- Timothy S. Chang,
- Yi Ding,
- Malika K. Freund,
- Ruth Johnson,
- Tommer Schwarz,
- Julie M. Yabu,
- Chad Hazlett,
- Jeffrey N. Chiang,
- David A. Wulf,
- Daniel H. Geschwind,
- Manish J. Butte,
- Bogdan Pasaniuc,
- Anna L. Antonio,
- Maryam Ariannejad,
- Angela M. Badillo,
- Brunilda Balliu,
- Yael Berkovich,
- Michael Broudy,
- Tony Dang,
- Chris Denny,
- Eleazar Eskin,
- Eran Halperin,
- Brian L. Hill,
- Ankur Jain,
- Vivek Katakwar,
- Clara Lajonchere,
- Clara Magyar,
- Sheila Minton,
- Ghouse Mohammed,
- Ariff Muhamed,
- Pabba Pavan,
- Michael A. Pfeffer,
- Nadav Rakocz,
- Akos Rudas,
- Rey Salonga,
- Timothy J. Sanders,
- Paul Tung,
- Vu Vu,
- Ailsa Zheng
Affiliations
- Timothy S. Chang
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Corresponding author
- Yi Ding
- Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Malika K. Freund
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Ruth Johnson
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Tommer Schwarz
- Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Julie M. Yabu
- Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
- Chad Hazlett
- Department of Political Science, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Statistics, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Jeffrey N. Chiang
- Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
- David A. Wulf
- Department of Political Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Daniel H. Geschwind
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute of Precision Health, University of California, Los Angeles, Los Angeles, CA 90095, USA
- Manish J. Butte
- Divisions of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Corresponding author
- Bogdan Pasaniuc
- Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Corresponding author
- Anna L. Antonio
- Maryam Ariannejad
- Angela M. Badillo
- Brunilda Balliu
- Yael Berkovich
- Michael Broudy
- Tony Dang
- Chris Denny
- Eleazar Eskin
- Eran Halperin
- Brian L. Hill
- Ankur Jain
- Vivek Katakwar
- Clara Lajonchere
- Clara Magyar
- Sheila Minton
- Ghouse Mohammed
- Ariff Muhamed
- Pabba Pavan
- Michael A. Pfeffer
- Nadav Rakocz
- Akos Rudas
- Rey Salonga
- Timothy J. Sanders
- Paul Tung
- Vu Vu
- Ailsa Zheng
- Journal volume & issue
-
Vol. 24,
no. 3
p. 102188
Abstract
Summary: Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.
