Nature Communications (Jul 2017)
RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
- Kyeongkyu Kim,
- Kyungjin Boo,
- Young Suk Yu,
- Se Kyu Oh,
- Hyunkyung Kim,
- Yoon Jeon,
- Jinhyuk Bhin,
- Daehee Hwang,
- Keun Il Kim,
- Jun-Su Lee,
- Seung-Soon Im,
- Seul Gi Yoon,
- Il Yong Kim,
- Je Kyung Seong,
- Ho Lee,
- Sungsoon Fang,
- Sung Hee Baek
Affiliations
- Kyeongkyu Kim
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- Kyungjin Boo
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- Young Suk Yu
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- Se Kyu Oh
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- Hyunkyung Kim
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- Yoon Jeon
- Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center
- Jinhyuk Bhin
- Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST
- Daehee Hwang
- Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST
- Keun Il Kim
- Department of Biological Sciences, Sookmyung Women’s University
- Jun-Su Lee
- Department of Physiology, Keimyung University School of Medicine
- Seung-Soon Im
- Department of Physiology, Keimyung University School of Medicine
- Seul Gi Yoon
- Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University
- Il Yong Kim
- Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University
- Je Kyung Seong
- Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University
- Ho Lee
- Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center
- Sungsoon Fang
- Severance Biomedical Science Institute, BK21 Plus Project for Medical Science, Gangnam Severance Hospital, Yonsei University College of Medicine
- Sung Hee Baek
- Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-017-00215-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes.
