Nature Communications (Nov 2020)
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
- Fatai S. Oladunni,
- Jun-Gyu Park,
- Paula A. Pino,
- Olga Gonzalez,
- Anwari Akhter,
- Anna Allué-Guardia,
- Angélica Olmo-Fontánez,
- Shalini Gautam,
- Andreu Garcia-Vilanova,
- Chengjin Ye,
- Kevin Chiem,
- Colwyn Headley,
- Varun Dwivedi,
- Laura M. Parodi,
- Kendra J. Alfson,
- Hilary M. Staples,
- Alyssa Schami,
- Juan I. Garcia,
- Alison Whigham,
- Roy Neal Platt,
- Michal Gazi,
- Jesse Martinez,
- Colin Chuba,
- Stephanie Earley,
- Oscar H. Rodriguez,
- Stephanie Davis Mdaki,
- Katrina N. Kavelish,
- Renee Escalona,
- Cory R. A. Hallam,
- Corbett Christie,
- Jean L. Patterson,
- Tim J. C. Anderson,
- Ricardo Carrion,
- Edward J. Dick,
- Shannan Hall-Ursone,
- Larry S. Schlesinger,
- Xavier Alvarez,
- Deepak Kaushal,
- Luis D. Giavedoni,
- Joanne Turner,
- Luis Martinez-Sobrido,
- Jordi B. Torrelles
Affiliations
- Fatai S. Oladunni
- Texas Biomedical Research Institute
- Jun-Gyu Park
- Texas Biomedical Research Institute
- Paula A. Pino
- Texas Biomedical Research Institute
- Olga Gonzalez
- Texas Biomedical Research Institute
- Anwari Akhter
- Texas Biomedical Research Institute
- Anna Allué-Guardia
- Texas Biomedical Research Institute
- Angélica Olmo-Fontánez
- Texas Biomedical Research Institute
- Shalini Gautam
- Texas Biomedical Research Institute
- Andreu Garcia-Vilanova
- Texas Biomedical Research Institute
- Chengjin Ye
- Texas Biomedical Research Institute
- Kevin Chiem
- Texas Biomedical Research Institute
- Colwyn Headley
- Texas Biomedical Research Institute
- Varun Dwivedi
- Texas Biomedical Research Institute
- Laura M. Parodi
- Texas Biomedical Research Institute
- Kendra J. Alfson
- Texas Biomedical Research Institute
- Hilary M. Staples
- Texas Biomedical Research Institute
- Alyssa Schami
- Texas Biomedical Research Institute
- Juan I. Garcia
- Texas Biomedical Research Institute
- Alison Whigham
- Texas Biomedical Research Institute
- Roy Neal Platt
- Texas Biomedical Research Institute
- Michal Gazi
- Texas Biomedical Research Institute
- Jesse Martinez
- Texas Biomedical Research Institute
- Colin Chuba
- Texas Biomedical Research Institute
- Stephanie Earley
- Texas Biomedical Research Institute
- Oscar H. Rodriguez
- Texas Biomedical Research Institute
- Stephanie Davis Mdaki
- Texas Biomedical Research Institute
- Katrina N. Kavelish
- Texas Biomedical Research Institute
- Renee Escalona
- Texas Biomedical Research Institute
- Cory R. A. Hallam
- Texas Biomedical Research Institute
- Corbett Christie
- Texas Biomedical Research Institute
- Jean L. Patterson
- Texas Biomedical Research Institute
- Tim J. C. Anderson
- Texas Biomedical Research Institute
- Ricardo Carrion
- Texas Biomedical Research Institute
- Edward J. Dick
- Texas Biomedical Research Institute
- Shannan Hall-Ursone
- Texas Biomedical Research Institute
- Larry S. Schlesinger
- Texas Biomedical Research Institute
- Xavier Alvarez
- Texas Biomedical Research Institute
- Deepak Kaushal
- Texas Biomedical Research Institute
- Luis D. Giavedoni
- Texas Biomedical Research Institute
- Joanne Turner
- Texas Biomedical Research Institute
- Luis Martinez-Sobrido
- Texas Biomedical Research Institute
- Jordi B. Torrelles
- Texas Biomedical Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-19891-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation.
