Nature Communications (Jun 2018)
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
- Tokhir Dadaev,
- Edward J. Saunders,
- Paul J. Newcombe,
- Ezequiel Anokian,
- Daniel A. Leongamornlert,
- Mark N. Brook,
- Clara Cieza-Borrella,
- Martina Mijuskovic,
- Sarah Wakerell,
- Ali Amin Al Olama,
- Fredrick R. Schumacher,
- Sonja I. Berndt,
- Sara Benlloch,
- Mahbubl Ahmed,
- Chee Goh,
- Xin Sheng,
- Zhuo Zhang,
- Kenneth Muir,
- Koveela Govindasami,
- Artitaya Lophatananon,
- Victoria L. Stevens,
- Susan M. Gapstur,
- Brian D. Carter,
- Catherine M. Tangen,
- Phyllis Goodman,
- Ian M. Thompson,
- Jyotsna Batra,
- Suzanne Chambers,
- Leire Moya,
- Judith Clements,
- Lisa Horvath,
- Wayne Tilley,
- Gail Risbridger,
- Henrik Gronberg,
- Markus Aly,
- Tobias Nordström,
- Paul Pharoah,
- Nora Pashayan,
- Johanna Schleutker,
- Teuvo L. J. Tammela,
- Csilla Sipeky,
- Anssi Auvinen,
- Demetrius Albanes,
- Stephanie Weinstein,
- Alicja Wolk,
- Niclas Hakansson,
- Catharine West,
- Alison M. Dunning,
- Neil Burnet,
- Lorelei Mucci,
- Edward Giovannucci,
- Gerald Andriole,
- Olivier Cussenot,
- Géraldine Cancel-Tassin,
- Stella Koutros,
- Laura E. Beane Freeman,
- Karina Dalsgaard Sorensen,
- Torben Falck Orntoft,
- Michael Borre,
- Lovise Maehle,
- Eli Marie Grindedal,
- David E. Neal,
- Jenny L. Donovan,
- Freddie C. Hamdy,
- Richard M. Martin,
- Ruth C. Travis,
- Tim J. Key,
- Robert J. Hamilton,
- Neil E. Fleshner,
- Antonio Finelli,
- Sue Ann Ingles,
- Mariana C. Stern,
- Barry Rosenstein,
- Sarah Kerns,
- Harry Ostrer,
- Yong-Jie Lu,
- Hong-Wei Zhang,
- Ninghan Feng,
- Xueying Mao,
- Xin Guo,
- Guomin Wang,
- Zan Sun,
- Graham G. Giles,
- Melissa C. Southey,
- Robert J. MacInnis,
- Liesel M. FitzGerald,
- Adam S. Kibel,
- Bettina F. Drake,
- Ana Vega,
- Antonio Gómez-Caamaño,
- Laura Fachal,
- Robert Szulkin,
- Martin Eklund,
- Manolis Kogevinas,
- Javier Llorca,
- Gemma Castaño-Vinyals,
- Kathryn L. Penney,
- Meir Stampfer,
- Jong Y. Park,
- Thomas A. Sellers,
- Hui-Yi Lin,
- Janet L. Stanford,
- Cezary Cybulski,
- Dominika Wokolorczyk,
- Jan Lubinski,
- Elaine A. Ostrander,
- Milan S. Geybels,
- Børge G. Nordestgaard,
- Sune F. Nielsen,
- Maren Weisher,
- Rasmus Bisbjerg,
- Martin Andreas Røder,
- Peter Iversen,
- Hermann Brenner,
- Katarina Cuk,
- Bernd Holleczek,
- Christiane Maier,
- Manuel Luedeke,
- Thomas Schnoeller,
- Jeri Kim,
- Christopher J. Logothetis,
- Esther M. John,
- Manuel R. Teixeira,
- Paula Paulo,
- Marta Cardoso,
- Susan L. Neuhausen,
- Linda Steele,
- Yuan Chun Ding,
- Kim De Ruyck,
- Gert De Meerleer,
- Piet Ost,
- Azad Razack,
- Jasmine Lim,
- Soo-Hwang Teo,
- Daniel W. Lin,
- Lisa F. Newcomb,
- Davor Lessel,
- Marija Gamulin,
- Tomislav Kulis,
- Radka Kaneva,
- Nawaid Usmani,
- Chavdar Slavov,
- Vanio Mitev,
- Matthew Parliament,
- Sandeep Singhal,
- Frank Claessens,
- Steven Joniau,
- Thomas Van den Broeck,
- Samantha Larkin,
- Paul A. Townsend,
- Claire Aukim-Hastie,
- Manuela Gago-Dominguez,
- Jose Esteban Castelao,
- Maria Elena Martinez,
- Monique J. Roobol,
- Guido Jenster,
- Ron H. N. van Schaik,
- Florence Menegaux,
- Thérèse Truong,
- Yves Akoli Koudou,
- Jianfeng Xu,
- Kay-Tee Khaw,
- Lisa Cannon-Albright,
- Hardev Pandha,
- Agnieszka Michael,
- Andrzej Kierzek,
- Stephen N. Thibodeau,
- Shannon K. McDonnell,
- Daniel J. Schaid,
- Sara Lindstrom,
- Constance Turman,
- Jing Ma,
- David J. Hunter,
- Elio Riboli,
- Afshan Siddiq,
- Federico Canzian,
- Laurence N. Kolonel,
- Loic Le Marchand,
- Robert N. Hoover,
- Mitchell J. Machiela,
- Peter Kraft,
- The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium,
- Matthew Freedman,
- Fredrik Wiklund,
- Stephen Chanock,
- Brian E. Henderson,
- Douglas F. Easton,
- Christopher A. Haiman,
- Rosalind A. Eeles,
- David V. Conti,
- Zsofia Kote-Jarai
Affiliations
- Tokhir Dadaev
- The Institute of Cancer Research
- Edward J. Saunders
- The Institute of Cancer Research
- Paul J. Newcombe
- MRC Biostatistics Unit, University of Cambridge
- Ezequiel Anokian
- The Institute of Cancer Research
- Daniel A. Leongamornlert
- The Institute of Cancer Research
- Mark N. Brook
- The Institute of Cancer Research
- Clara Cieza-Borrella
- The Institute of Cancer Research
- Martina Mijuskovic
- The Institute of Cancer Research
- Sarah Wakerell
- The Institute of Cancer Research
- Ali Amin Al Olama
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Fredrick R. Schumacher
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Sara Benlloch
- The Institute of Cancer Research
- Mahbubl Ahmed
- The Institute of Cancer Research
- Chee Goh
- The Institute of Cancer Research
- Xin Sheng
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Zhuo Zhang
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Koveela Govindasami
- The Institute of Cancer Research
- Artitaya Lophatananon
- Institute of Population Health, University of Manchester
- Victoria L. Stevens
- Epidemiology Research Program, American Cancer Society
- Susan M. Gapstur
- Epidemiology Research Program, American Cancer Society
- Brian D. Carter
- Epidemiology Research Program, American Cancer Society
- Catherine M. Tangen
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Phyllis Goodman
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Ian M. Thompson
- CHRISTUS Santa Rosa Hospital - Medical Center
- Jyotsna Batra
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Suzanne Chambers
- Menzies Health Institute Queensland, Griffith University
- Leire Moya
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Judith Clements
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Lisa Horvath
- Chris O’Brien Lifehouse (COBLH), Camperdown
- Wayne Tilley
- Dame Roma Mitchell Cancer Research Centre, University of Adelaide
- Gail Risbridger
- Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University
- Henrik Gronberg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Markus Aly
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Tobias Nordström
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Paul Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Nora Pashayan
- Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge
- Johanna Schleutker
- Institute of Biomedicine, University of Turku
- Teuvo L. J. Tammela
- Department of Urology, Tampere University Hospital, University of Tampere
- Csilla Sipeky
- Institute of Biomedicine, University of Turku
- Anssi Auvinen
- Department of Epidemiology, School of Health Sciences, University of Tampere
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Stephanie Weinstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Alicja Wolk
- Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Niclas Hakansson
- Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Catharine West
- Division of Cancer Sciences, Manchester Academic Health Science Centre, Radiotherapy Related Research, Manchester NIHR Biomedical Research Centre, The Christie Hospital NHS Foundation Trust, University of Manchester
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge
- Neil Burnet
- University of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust
- Lorelei Mucci
- Department of Epidemiology, Harvard School of Public Health
- Edward Giovannucci
- Department of Epidemiology, Harvard School of Public Health
- Gerald Andriole
- Washington University School of Medicine
- Olivier Cussenot
- GRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital
- Géraldine Cancel-Tassin
- GRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital
- Stella Koutros
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Laura E. Beane Freeman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Karina Dalsgaard Sorensen
- Department of Molecular Medicine, Aarhus University Hospital
- Torben Falck Orntoft
- Department of Molecular Medicine, Aarhus University Hospital
- Michael Borre
- Department of Clinical Medicine, Aarhus University
- Lovise Maehle
- Department of Medical Genetics, Oslo University Hospital
- Eli Marie Grindedal
- Department of Medical Genetics, Oslo University Hospital
- David E. Neal
- Department of Oncology, Addenbrooke’s Hospital, University of Cambridge
- Jenny L. Donovan
- School of Social and Community Medicine, University of Bristol
- Freddie C. Hamdy
- Nuffield Department of Surgical Sciences, University of Oxford
- Richard M. Martin
- School of Social and Community Medicine, University of Bristol
- Ruth C. Travis
- Cancer Epidemiology, Nuffield Department of Population Health, University of Oxford
- Tim J. Key
- Cancer Epidemiology, Nuffield Department of Population Health, University of Oxford
- Robert J. Hamilton
- Department of Surgical Oncology, Princess Margaret Cancer Centre
- Neil E. Fleshner
- Department of Surgical Oncology, Princess Margaret Cancer Centre
- Antonio Finelli
- Department of Surgical Oncology, Princess Margaret Cancer Centre
- Sue Ann Ingles
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Mariana C. Stern
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Barry Rosenstein
- Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
- Sarah Kerns
- Department of Radiation Oncology, University of Rochester Medical Center
- Harry Ostrer
- Professor of Pathology and Pediatrics, Albert Einstein College of Medicine
- Yong-Jie Lu
- Centre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Queen Mary University of London
- Hong-Wei Zhang
- Second Military Medical University
- Ninghan Feng
- Wuxi Second Hospital, Nanjing Medical University
- Xueying Mao
- Centre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Queen Mary University of London
- Xin Guo
- Department of Urology, The First Affiliated Hospital, Chongqing Medical University
- Guomin Wang
- Department of Urology, Zhongshan Hospital, Fudan University Medical College
- Zan Sun
- The People’s Hospital of Liaoning Province and The People’s Hospital of China Medical University
- Graham G. Giles
- Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
- Melissa C. Southey
- Precision Medicine, School and Clinical Sciences at Monash Health, Monash University
- Robert J. MacInnis
- Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
- Liesel M. FitzGerald
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Adam S. Kibel
- Division of Urologic Surgery, Brigham and Womens Hospital
- Bettina F. Drake
- Washington University School of Medicine
- Ana Vega
- Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS
- Antonio Gómez-Caamaño
- Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS
- Laura Fachal
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Robert Szulkin
- Division of Family Medicine, Department of Neurobiology, Care Science and Society, Karolinska Institutet
- Martin Eklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Manolis Kogevinas
- Centre for Research in Environmental Epidemiology (CREAL), Barcelona Institute for Global Health (ISGlobal)
- Javier Llorca
- CIBER Epidemiología y Salud Pública (CIBERESP)
- Gemma Castaño-Vinyals
- Centre for Research in Environmental Epidemiology (CREAL), Barcelona Institute for Global Health (ISGlobal)
- Kathryn L. Penney
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School
- Meir Stampfer
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School
- Jong Y. Park
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Thomas A. Sellers
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Hui-Yi Lin
- School of Public Health, Louisiana State University Health Sciences Center
- Janet L. Stanford
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Cezary Cybulski
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University
- Dominika Wokolorczyk
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University
- Jan Lubinski
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University
- Elaine A. Ostrander
- National Human Genome Research Institute, National Institutes of Health
- Milan S. Geybels
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Børge G. Nordestgaard
- Faculty of Health and Medical Sciences, University of Copenhagen
- Sune F. Nielsen
- Faculty of Health and Medical Sciences, University of Copenhagen
- Maren Weisher
- Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Rasmus Bisbjerg
- Department of Urology, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Martin Andreas Røder
- Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital
- Peter Iversen
- Faculty of Health and Medical Sciences, University of Copenhagen
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Katarina Cuk
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Bernd Holleczek
- Saarland Cancer Registry
- Christiane Maier
- Institute for Human Genetics, University Hospital Ulm
- Manuel Luedeke
- Institute for Human Genetics, University Hospital Ulm
- Thomas Schnoeller
- Department of Urology, University Hospital Ulm
- Jeri Kim
- Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
- Christopher J. Logothetis
- Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
- Esther M. John
- Cancer Prevention Institute of California
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute of Porto
- Paula Paulo
- Department of Genetics, Portuguese Oncology Institute of Porto
- Marta Cardoso
- Department of Genetics, Portuguese Oncology Institute of Porto
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of the City of Hope
- Linda Steele
- Department of Population Sciences, Beckman Research Institute of the City of Hope
- Yuan Chun Ding
- Department of Population Sciences, Beckman Research Institute of the City of Hope
- Kim De Ruyck
- Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences
- Gert De Meerleer
- Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences
- Piet Ost
- Department of Radiotherapy, Ghent University Hospital
- Azad Razack
- Department of Surgery, Faculty of Medicine, University of Malaya
- Jasmine Lim
- Department of Surgery, Faculty of Medicine, University of Malaya
- Soo-Hwang Teo
- Cancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre
- Daniel W. Lin
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Lisa F. Newcomb
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Davor Lessel
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf
- Marija Gamulin
- Division of Medical Oncology, Urogenital Unit, Department of Oncology at the University Hospital Centre Zagreb
- Tomislav Kulis
- Department of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine
- Radka Kaneva
- Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia
- Nawaid Usmani
- Department of Oncology, Cross Cancer Institute, University of Alberta
- Chavdar Slavov
- Department of Urology and Alexandrovska University Hospital, Medical University of Sofia
- Vanio Mitev
- Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia
- Matthew Parliament
- Department of Oncology, Cross Cancer Institute, University of Alberta
- Sandeep Singhal
- Department of Oncology, Cross Cancer Institute, University of Alberta
- Frank Claessens
- Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven
- Steven Joniau
- Department of Urology, University Hospitals Leuven
- Thomas Van den Broeck
- Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven
- Samantha Larkin
- Southampton General Hospital, The University of Southampton
- Paul A. Townsend
- Manchester Cancer Research Centre, Faculty of Biology Medicine & Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester
- Claire Aukim-Hastie
- The University of Surrey
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
- Jose Esteban Castelao
- Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS)
- Maria Elena Martinez
- Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego
- Monique J. Roobol
- Department of Urology, Erasmus University Medical Center
- Guido Jenster
- Department of Urology, Erasmus University Medical Center
- Ron H. N. van Schaik
- Department of Clinical Chemistry, Erasmus University Medical Center
- Florence Menegaux
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Thérèse Truong
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Yves Akoli Koudou
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Jianfeng Xu
- Program for Personalized Cancer Care, NorthShore University HealthSystem
- Kay-Tee Khaw
- Clinical Gerontology Unit, University of Cambridge
- Lisa Cannon-Albright
- Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine
- Hardev Pandha
- The University of Surrey
- Agnieszka Michael
- The University of Surrey
- Andrzej Kierzek
- The University of Surrey
- Stephen N. Thibodeau
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Shannon K. McDonnell
- Division of Biomedical Statistics & Informatics, Mayo Clinic
- Daniel J. Schaid
- Division of Biomedical Statistics & Informatics, Mayo Clinic
- Sara Lindstrom
- Department of Epidemiology, University of Washington
- Constance Turman
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Jing Ma
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School
- David J. Hunter
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College
- Afshan Siddiq
- Genomics England, Queen Mary University of London
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Laurence N. Kolonel
- Epidemiology Program, University of Hawaii Cancer Center
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Robert N. Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
- Matthew Freedman
- Dana-Farber Cancer Institute
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Brian E. Henderson
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Rosalind A. Eeles
- The Institute of Cancer Research
- David V. Conti
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Zsofia Kote-Jarai
- The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-018-04109-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.
