Mechanisms of cell death and proliferation of aldosterone-producing adenoma

Abstract

Aldosterone-producing adenoma (APA) is one of the main causes of primary aldosteronism (PA). Current researches on its autonomous secretion of aldosterone mainly focus on the detection of somatic driver genetic mutations. However, the specific mechanisms underlying the death and proliferation of adrenal cortical cells and the occurrence and development of adenomas are still unclear. This study aims to review the research progress on the mechanisms of cell death and proliferation of APA by combining previously published studies on genomics, transcriptomics, metabolomics, and epigenetics related to adrenal tissues.

Keywords

• primary aldosteronism|aldosterone-producing adenoma|cell proliferation and apoptosis|signaling pathway|multi-omics study