mBio
(Jun 2021)
Engineering the Modular Receptor-Binding Proteins of
<i>Klebsiella</i>
Phages Switches Their Capsule Serotype Specificity
Agnieszka Latka,
Sebastien Lemire,
Dennis Grimon,
Dorien Dams,
Barbara Maciejewska,
Timothy Lu,
Zuzanna Drulis-Kawa,
Yves Briers
Affiliations
Agnieszka Latka
ORCiD Department of Biotechnology, Ghent University, Ghent, Belgium
Sebastien Lemire
Synthetic Biology Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Dennis Grimon
Department of Biotechnology, Ghent University, Ghent, Belgium
Dorien Dams
Department of Biotechnology, Ghent University, Ghent, Belgium
Barbara Maciejewska
Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland
Timothy Lu
Synthetic Biology Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Zuzanna Drulis-Kawa
ORCiD Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland
Yves Briers
ORCiD Department of Biotechnology, Ghent University, Ghent, Belgium
DOI
https://doi.org/10.1128/mBio.00455-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.
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