[Bmim]PF6: An efficient tool for the synthesis of diverse bioactive heterocycles

Abstract

Heterocycles are the privileged structural subunit of many marketed drug molecules. On the other hand, the last decade has seen tremendous applications of the ionic liquid [bmim]PF6 (1-butyl-3-methyl-1H-imidazolium hexafluorophosphate) as an efficient, cheap, commercially available, low toxic reaction medium for various organic transformations. The present review summarizes recent reported applications of [bmim]PF6 as an efficient reaction medium for the synthesis of diverse biologically relevant heterocycles.

Keywords

• [Bmim]PF6
• heterocycles
• hexafluorophosphate
• imidazolium
• P-ionic liquid