Modern possibilities of sodium hyaluronate in tear substitutive therapy of patients with “dry eye” syndrome

Abstract

V.V. Brzheskiy, V.Yu. Popov St. Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation At present, artificial tear preparations based on sodium hyaluronate account for 53.3% of the total of 45 tear substitutes registered in Russia, of which 72.7% are from 22 of their non-preservative forms. The positive properties of hyaluronic acid (hygroscopicity, mucoadhesiveness, high tolerability when instilled into the conjunctival cavity) provide long-lasting hydration of an eye surface during its xerosis and cause high clinical efficacy in the treatment of patients with “dry eye” syndrome (DES). The same properties are naturally possessed by such preparations as Vismed, Vismed light, Vismed multi and Vismed gel, based on the sodium salt of the high molecular weight hyaluronic acid. In a number of experimental studies, the efficacy and safety of the Vismed line is proved: in vitro — on the culture of epithelial cells of the human conjunctiva, in vivo — on the model of traumatic corneal erosion in rabbits. The results of the experiments were further confirmed by clinical studies in the treatment of patients with DES of various origins. In this case, the Vismed line was more effective than solutions of carboxymethylcellulose, hydroxypropylmethylcellulose, carbomer 934P, and other compounds widely used in tear substitutive therapy. Key words: hyaluronic acid, artificial tear preparations, “dry eye” syndrome, Vismed. For citation: Brzheskiy V.V., Popov V.Yu. Modern possibilities of sodium hyaluronate in tear substitutive therapy of patients with  “dry eye”syndrome. RMJ “Clinical ophthalmology”. 2018;4:179–185.