Will the Bacteria Survive in the CeO<sub>2</sub> Nanozyme-H<sub>2</sub>O<sub>2</sub> System?
Weisheng Zhu,
Luyao Wang,
Qisi Li,
Lizhi Jiao,
Xiaokan Yu,
Xiangfan Gao,
Hao Qiu,
Zhijun Zhang,
Wei Bing
Affiliations
Weisheng Zhu
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Luyao Wang
School of Chemistry and Life Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, China
Qisi Li
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Lizhi Jiao
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Xiaokan Yu
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Xiangfan Gao
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Hao Qiu
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Zhijun Zhang
Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Wei Bing
School of Chemistry and Life Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, China
As one of the nanostructures with enzyme-like activity, nanozymes have recently attracted extensive attention for their biomedical applications, especially for bacterial disinfection treatment. Nanozymes with high peroxidase activity are considered to be excellent candidates for building bacterial disinfection systems (nanozyme-H2O2), in which the nanozyme will promote the generation of ROS to kill bacteria based on the decomposition of H2O2. According to this criterion, a cerium oxide nanoparticle (Nanoceria, CeO2, a classical nanozyme with high peroxidase activity)-based nanozyme-H2O2 system would be very efficient for bacterial disinfection. However, CeO2 is a nanozyme with multiple enzyme-like activities. In addition to high peroxidase activity, CeO2 nanozymes also possess high superoxide dismutase activity and antioxidant activity, which can act as a ROS scavenger. Considering the fact that CeO2 nanozymes have both the activity to promote ROS production and the opposite activity for ROS scavenging, it is worth exploring which activity will play the dominating role in the CeO2-H2O2 system, as well as whether it will protect bacteria or produce an antibacterial effect. In this work, we focused on this discussion to unveil the role of CeO2 in the CeO2-H2O2 system, so that it can provide valuable knowledge for the design of a nanozyme-H2O2-based antibacterial system.
