Nature Communications (Jun 2022)
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
- Biao Zhou,
- Runhong Zhou,
- Bingjie Tang,
- Jasper Fuk-Woo Chan,
- Mengxiao Luo,
- Qiaoli Peng,
- Shuofeng Yuan,
- Hang Liu,
- Bobo Wing-Yee Mok,
- Bohao Chen,
- Pui Wang,
- Vincent Kwok-Man Poon,
- Hin Chu,
- Chris Chung-Sing Chan,
- Jessica Oi-Ling Tsang,
- Chris Chun-Yiu Chan,
- Ka-Kit Au,
- Hiu-On Man,
- Lu Lu,
- Kelvin Kai-Wang To,
- Honglin Chen,
- Kwok-Yung Yuen,
- Shangyu Dang,
- Zhiwei Chen
Affiliations
- Biao Zhou
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Runhong Zhou
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Bingjie Tang
- Division of Life Science, The Hong Kong University of Science and Technology
- Jasper Fuk-Woo Chan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Mengxiao Luo
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Qiaoli Peng
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Shuofeng Yuan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hang Liu
- Division of Life Science, The Hong Kong University of Science and Technology
- Bobo Wing-Yee Mok
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Bohao Chen
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Pui Wang
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Vincent Kwok-Man Poon
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hin Chu
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chris Chung-Sing Chan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jessica Oi-Ling Tsang
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chris Chun-Yiu Chan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Ka-Kit Au
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hiu-On Man
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Lu Lu
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kelvin Kai-Wang To
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Honglin Chen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kwok-Yung Yuen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Shangyu Dang
- Division of Life Science, The Hong Kong University of Science and Technology
- Zhiwei Chen
- AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-022-31259-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.
