SNAIL1: Linking Tumor Metastasis to Immune Evasion

Xiaolong Tang; Xue Sui; Liang Weng; Liang Weng; Liang Weng; Liang Weng; Liang Weng; Liang Weng; Yongshuo Liu; Yongshuo Liu

doi:10.3389/fimmu.2021.724200

Frontiers in Immunology (Nov 2021)

SNAIL1: Linking Tumor Metastasis to Immune Evasion

Xiaolong Tang,
Xue Sui,
Liang Weng,
Liang Weng,
Liang Weng,
Liang Weng,
Liang Weng,
Liang Weng,
Yongshuo Liu,
Yongshuo Liu

Affiliations

Xiaolong Tang: Department of Laboratory Medicine, Binzhou Medical University, Binzhou, China
Xue Sui: Department of Laboratory Medicine, Binzhou Medical University, Binzhou, China
Liang Weng: Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, China
Liang Weng: Key Laboratory of Molecular Radiation Oncology Hunan Province, Xiangya Hospital, Central South University, Changsha, China
Liang Weng: Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Xiangya Hospital, Central South University, Changsha, China
Liang Weng: Hunan Provincial Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, China
Liang Weng: Institute of Gerontological Cancer Research, National Clinical Research Center for Gerontology, Changsha, China
Liang Weng: Center for Molecular Imaging of Central South University, Xiangya Hospital, Changsha, China
Yongshuo Liu: Department of Clinical Laboratory, Binzhou Medical University Hospital, Binzhou, China
Yongshuo Liu: Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China

DOI: https://doi.org/10.3389/fimmu.2021.724200
Journal volume & issue: Vol. 12

Abstract

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The transcription factor Snail1, a key inducer of epithelial-mesenchymal transition (EMT), plays a critical role in tumor metastasis. Its stability is strictly controlled by multiple intracellular signal transduction pathways and the ubiquitin-proteasome system (UPS). Increasing evidence indicates that methylation and acetylation of Snail1 also affects tumor metastasis. More importantly, Snail1 is involved in tumor immunosuppression by inducing chemokines and immunosuppressive cells into the tumor microenvironment (TME). In addition, some immune checkpoints potentiate Snail1 expression, such as programmed death ligand 1 (PD-L1) and T cell immunoglobulin 3 (TIM-3). This mini review highlights the pathways and molecules involved in maintenance of Snail1 level and the significance of Snail1 in tumor immune evasion. Due to the crucial role of EMT in tumor metastasis and tumor immunosuppression, comprehensive understanding of Snail1 function may contribute to the development of novel therapeutics for cancer.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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