Infection and Drug Resistance (Aug 2022)

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

  • Liang S,
  • Cao H,
  • Ying F,
  • Zhang C

Journal volume & issue
Vol. Volume 15
pp. 4749 – 4757

Abstract

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Shiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Ying, Tel +86 13985509788, Email [email protected]: The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by Klebsiella pneumoniae (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.Keywords: purulent pericarditis, Klebsiella pneumoniae, carbapenem-resistance, hypervirulence, ST11, K64

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