Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

Tao Yu; Yongjin J. Zhou; Leonie Wenning; Quanli Liu; Anastasia Krivoruchko; Verena Siewers; Jens Nielsen; Florian David

doi:10.1038/ncomms15587

Nature Communications (May 2017)

Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

Tao Yu,
Yongjin J. Zhou,
Leonie Wenning,
Quanli Liu,
Anastasia Krivoruchko,
Verena Siewers,
Jens Nielsen,
Florian David

Affiliations

Tao Yu: Department of Biology and Biological Engineering, Chalmers University of Technology
Yongjin J. Zhou: Department of Biology and Biological Engineering, Chalmers University of Technology
Leonie Wenning: Department of Biology and Biological Engineering, Chalmers University of Technology
Quanli Liu: Department of Biology and Biological Engineering, Chalmers University of Technology
Anastasia Krivoruchko: Department of Biology and Biological Engineering, Chalmers University of Technology
Verena Siewers: Department of Biology and Biological Engineering, Chalmers University of Technology
Jens Nielsen: Department of Biology and Biological Engineering, Chalmers University of Technology
Florian David: Department of Biology and Biological Engineering, Chalmers University of Technology

DOI: https://doi.org/10.1038/ncomms15587
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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