Research progress on anti-viral treatment for chronic hepatitis B patients with high viral load

Abstract

Chronic hepatitis B （CHB） is a severe disease that affects human health. Replication of hepatitis B virus （HBV） is the main cause of morbidity in CHB patients. High viral load is a high-risk factor for CHB progressing into liver cirrhosis or hepatocellular carcinoma. Anti-viral therapy plays a significant role in the treatment of CHB patients with high viral load. In clinical practice, CHB patients with high viral load yield low virological response rate. In recent clinical trials, anti-viral therapy has become the hotspot and challenge. In this article, research progresses on anti-viral therapy for CHB patients with high viral load were reviewed.

Keywords

• |high viral load|chronic hepatitis b|anti-viral therapy