Neural Regeneration Research (Jan 2015)
Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH
- Li Sun,
- Qin Li,
- Wei-ting Wang,
- Yu-hua Chen,
- Lian-jun Guo
Affiliations
- Li Sun
- Qin Li
- Wei-ting Wang
- Yu-hua Chen
- Lian-jun Guo
- DOI
- https://doi.org/10.4103/1673-5374.155432
- Journal volume & issue
-
Vol. 10,
no. 4
pp. 589 – 593
Abstract
1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propane hydrochloride (DDPH) is a novel antihypertensive agent based on structural characteristics of mexiletine and verapamine. We investigated the effect of DDPH on vasodilatation and neuroprotection in a rat model of cerebral ischemia in vivo, and a rabbit model of isolated basilar arteries in vitro. Our results show that DDPH (10 mg/kg) significantly increased hippocampal blood flow in vivo in cerebral ischemic rats, and exerted dose-dependent relaxation of isolated basilar arteries contracted by histamine or KCl in the in vitro rabbit model. DDPH (3 × 10 -5 M) also inhibited histamine-stimulated extracellular calcium influx and intracellular calcium release. Our findings suggest that DDPH has a vasodilative effect both in vivo and in vitro, which mediates a neuroprotective effect on ischemic nerve tissue.
Keywords
- spinal cord injury
- propriospinal system
- neural plasticity
- fiber sprouting
- neural repair
- compensation
- regeneration
- propriospinal detours
- neurotrophic factors
- cell-adhesive ligands
- dorsal root ganglia
- L1CAM
- nerve growth factor
- biomaterials
- elastin-like proteins
- Alzheimer′s disease
- AMPK
- apoptosis
- autophagy
- central nervous system
- CCN4
- EGF
- diabetes mellitus
- erythropoietin
- EPO
- FGF
- IGF-1
- mTOR
- neuron
- neuropathy
- oxidative stress
- psychiatric
- stem cells
- WISP1
- Wnt
- peripheral nerve injury
- nerve graft
- nerve conduit
- Wallerian degeneration
- neurotrophic factors
- veins
- autografts
- nerve regeneration
- nerve regeneration
- neuroprotection
- resveratrol
- cerebral ischemia
- cerebral infarction
- matrix metalloproteinase
- molecular docking
- extracellular matrix
- neural regeneration
- nerve regeneration
- vagus nerve stimulation
- cerebral ischemia
- inflammatory cytokines
- infarct volume
- neurological function
- NSFC grants
- neural regeneration
- nerve regeneration
- Xingnao Kaiqiao needling method
- ischemic stroke
- randomized controlled trial
- systemic reviews
- meta-analysis
- long-term efficacy
- mortality
- recurrence
- disability
- adverse reactions
- health economics indicators
- neural regeneration
- nerve regeneration
- DDPH
- cerebral ischemia
- hippocampus
- blood flow
- isolated basilar artery
- dose-response curve
- NSFC grant
- neural regeneration