Nature Communications (Feb 2023)
Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice
- Sen Qiao,
- Samer Alasmi,
- Amanda Wyatt,
- Philipp Wartenberg,
- Hongmei Wang,
- Michael Candlish,
- Debajyoti Das,
- Mari Aoki,
- Ramona Grünewald,
- Ziyue Zhou,
- Qinghai Tian,
- Qiang Yu,
- Viktoria Götz,
- Anouar Belkacemi,
- Ahsan Raza,
- Fabien Ectors,
- Kathrin Kattler,
- Gilles Gasparoni,
- Jörn Walter,
- Peter Lipp,
- Patrice Mollard,
- Daniel J. Bernard,
- Ersin Karatayli,
- Senem Ceren Karatayli,
- Frank Lammert,
- Ulrich Boehm
Affiliations
- Sen Qiao
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Samer Alasmi
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Amanda Wyatt
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Philipp Wartenberg
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Hongmei Wang
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Michael Candlish
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Debajyoti Das
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Mari Aoki
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Ramona Grünewald
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Ziyue Zhou
- Department of Pharmacology and Therapeutics, McGill University
- Qinghai Tian
- Molecular Cell Biology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Qiang Yu
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Viktoria Götz
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Anouar Belkacemi
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Ahsan Raza
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Fabien Ectors
- FARAH Mammalian Transgenics Platform, Liège University
- Kathrin Kattler
- Department of Genetics and Epigenetics, Saarland University
- Gilles Gasparoni
- Department of Genetics and Epigenetics, Saarland University
- Jörn Walter
- Department of Genetics and Epigenetics, Saarland University
- Peter Lipp
- Molecular Cell Biology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- Patrice Mollard
- IGF, University of Montpellier, CNRS, INSERM
- Daniel J. Bernard
- Department of Pharmacology and Therapeutics, McGill University
- Ersin Karatayli
- Department of Medicine II, Saarland University Medical Center, Saarland University
- Senem Ceren Karatayli
- Department of Medicine II, Saarland University Medical Center, Saarland University
- Frank Lammert
- Department of Medicine II, Saarland University Medical Center, Saarland University
- Ulrich Boehm
- Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36681-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Gonadotropes in the pituitary secrete follicle-stimulating hormone and luteinizing hormone to control gonadal function and fertility, but whether they exert actions on extra-gonadal organs is not fully understood. Here the authors report that gonadotropes regulate liver steatosis independent of the ovaries in mice.
