Molecular & Cellular Oncology (Jan 2020)
Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
Abstract
Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation.