Nature Communications (Aug 2019)
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
- Yang Luo,
- Sara Suliman,
- Samira Asgari,
- Tiffany Amariuta,
- Yuriy Baglaenko,
- Marta Martínez-Bonet,
- Kazuyoshi Ishigaki,
- Maria Gutierrez-Arcelus,
- Roger Calderon,
- Leonid Lecca,
- Segundo R. León,
- Judith Jimenez,
- Rosa Yataco,
- Carmen Contreras,
- Jerome T. Galea,
- Mercedes Becerra,
- Sergey Nejentsev,
- Peter A. Nigrovic,
- D. Branch Moody,
- Megan B. Murray,
- Soumya Raychaudhuri
Affiliations
- Yang Luo
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Sara Suliman
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Samira Asgari
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Tiffany Amariuta
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Yuriy Baglaenko
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Marta Martínez-Bonet
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Kazuyoshi Ishigaki
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Maria Gutierrez-Arcelus
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Roger Calderon
- Socios En Salud
- Leonid Lecca
- Socios En Salud
- Segundo R. León
- Socios En Salud
- Judith Jimenez
- Socios En Salud
- Rosa Yataco
- Socios En Salud
- Carmen Contreras
- Socios En Salud
- Jerome T. Galea
- School of Social Work, University of South Florida
- Mercedes Becerra
- Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women’s Hospital, Harvard Medical School
- Sergey Nejentsev
- Department of Medicine, University of Cambridge
- Peter A. Nigrovic
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- D. Branch Moody
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Megan B. Murray
- Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women’s Hospital, Harvard Medical School
- Soumya Raychaudhuri
- Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-11664-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Between 5 and 15% of latent Mycobacterium tuberculosis infections develop into active tuberculosis (TB). Here, Luo et al. report a genome-wide association study for early TB progression in a total of 4002 active TB cases and their household contacts in Peru and they identify a locus on 3q23 in which ATP1B3 is mapped as the likely causal gene.
