Complete Genome Sequence Analysis of <i>Kribbella</i> sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters

Abstract

Minor genera actinomycetes are considered a promising source of new secondary metabolites. The strain Kribbella sp. CA-293567 produces sandramycin and kribbellichelins A & B In this work, we describe the complete genome sequencing of this strain and the in silico identification of biosynthetic gene clusters (BGCs), focusing on the pathways encoding sandramycin and kribbellichelins A–B. We also present a comparative analysis of the biosynthetic potential of 38 publicly available genomes from Kribbella strains.

Keywords

• <i>Kribbella</i>
• sandramycin
• kribbellichelin
• genome mining
• biosynthetic gene cluster
• minor genera of actinomycetes