Deep Segmentation Feature-Based Radiomics Improves Recurrence Prediction of Hepatocellular Carcinoma
Jifei Wang,
Dasheng Wu,
Meili Sun,
Zhenpeng Peng,
Yingyu Lin,
Hongxin Lin,
Jiazhao Chen,
Tingyu Long,
Zi-Ping Li,
Chuanmiao Xie,
Bingsheng Huang,
Shi-Ting Feng
Affiliations
Jifei Wang
Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Dasheng Wu
Medical AI Lab, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
Meili Sun
Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Zhenpeng Peng
Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Yingyu Lin
Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Hongxin Lin
Medical AI Lab, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
Jiazhao Chen
Medical AI Lab, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
Tingyu Long
Medical AI Lab, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
Zi-Ping Li
Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Chuanmiao Xie
Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Bingsheng Huang
Medical AI Lab, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
Shi-Ting Feng
Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Objective and Impact Statement. This study developed and validated a deep semantic segmentation feature-based radiomics (DSFR) model based on preoperative contrast-enhanced computed tomography (CECT) combined with clinical information to predict early recurrence (ER) of single hepatocellular carcinoma (HCC) after curative resection. ER prediction is of great significance to the therapeutic decision-making and surveillance strategy of HCC. Introduction. ER prediction is important for HCC. However, it cannot currently be adequately determined. Methods. Totally, 208 patients with single HCC after curative resection were retrospectively recruited into a model-development cohort (n=180) and an independent validation cohort (n=28). DSFR models based on different CT phases were developed. The optimal DSFR model was incorporated with clinical information to establish a DSFR-C model. An integrated nomogram based on the Cox regression was established. The DSFR signature was used to stratify high- and low-risk ER groups. Results. A portal phase-based DSFR model was selected as the optimal model (area under receiver operating characteristic curve (AUC): development cohort, 0.740; validation cohort, 0.717). The DSFR-C model achieved AUCs of 0.782 and 0.744 in the development and validation cohorts, respectively. In the development and validation cohorts, the integrated nomogram achieved C-index of 0.748 and 0.741 and time-dependent AUCs of 0.823 and 0.822, respectively, for recurrence-free survival (RFS) prediction. The RFS difference between the risk groups was statistically significant (P<0.0001 and P=0.045 in the development and validation cohorts, respectively). Conclusion. CECT-based DSFR can predict ER in single HCC after curative resection, and its combination with clinical information further improved the performance for ER prediction.
