Molecules
(Apr 2019)
New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>
Po-Yen Chen,
Chih-Chao Chang,
Hui-Chi Huang,
Li-Jie Zhang,
Chia-Ching Liaw,
Yu-Chi Lin,
Nham-Linh Nguyen,
Thanh-Hoa Vo,
Yung-Yi Cheng,
Susan L. Morris-Natschke,
Kuo-Hsiung Lee,
Yao-Haur Kuo
Affiliations
Po-Yen Chen
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Chih-Chao Chang
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Hui-Chi Huang
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Li-Jie Zhang
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Chia-Ching Liaw
Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan
Yu-Chi Lin
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Nham-Linh Nguyen
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Thanh-Hoa Vo
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Yung-Yi Cheng
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Susan L. Morris-Natschke
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Kuo-Hsiung Lee
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Yao-Haur Kuo
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
DOI
https://doi.org/10.3390/molecules24071375
Journal volume & issue
Vol. 24,
no. 7
Abstract
Read online
Six new dammarane-type saponins, gypenosides CP1-6 (1–6), along with 19 known compounds 7–25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).
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