Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Andres Ernesto Zucchetti; Laurence Bataille; Jean-Marie Carpier; Stéphanie Dogniaux; Mabel San Roman-Jouve; Mathieu Maurin; Michael W. Stuck; Rosa M. Rios; Cosima T. Baldari; Gregory J. Pazour; Claire Hivroz

doi:10.1038/s41467-019-10891-w

Nature Communications (Jun 2019)

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Andres Ernesto Zucchetti,
Laurence Bataille,
Jean-Marie Carpier,
Stéphanie Dogniaux,
Mabel San Roman-Jouve,
Mathieu Maurin,
Michael W. Stuck,
Rosa M. Rios,
Cosima T. Baldari,
Gregory J. Pazour,
Claire Hivroz

Affiliations

Andres Ernesto Zucchetti: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Laurence Bataille: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Jean-Marie Carpier: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Stéphanie Dogniaux: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Mabel San Roman-Jouve: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Mathieu Maurin: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team
Michael W. Stuck: Program in Molecular Medicine, University of Massachusetts Medical School
Rosa M. Rios: Cell Dynamics and Signaling Department, CABIMER-CSIC/US/UPO
Cosima T. Baldari: Department of Life Sciences, University of Siena
Gregory J. Pazour: Program in Molecular Medicine, University of Massachusetts Medical School
Claire Hivroz: Institut Curie, PSL Research University, INSERM U932, Integrative analysis of T cell activation team

DOI: https://doi.org/10.1038/s41467-019-10891-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically conveys LAT+ vesicles to immune synapse allowing proper T cell activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal