The 3D structure of lipidic fibrils of α-synuclein

Benedikt Frieg; Leif Antonschmidt; Christian Dienemann; James A. Geraets; Eszter E. Najbauer; Dirk Matthes; Bert L. de Groot; Loren B. Andreas; Stefan Becker; Christian Griesinger; Gunnar F. Schröder

doi:10.1038/s41467-022-34552-7

Nature Communications (Nov 2022)

The 3D structure of lipidic fibrils of α-synuclein

Benedikt Frieg,
Leif Antonschmidt,
Christian Dienemann,
James A. Geraets,
Eszter E. Najbauer,
Dirk Matthes,
Bert L. de Groot,
Loren B. Andreas,
Stefan Becker,
Christian Griesinger,
Gunnar F. Schröder

Affiliations

Benedikt Frieg: Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich
Leif Antonschmidt: Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences
Christian Dienemann: Department of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences
James A. Geraets: Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich
Eszter E. Najbauer: Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences
Dirk Matthes: Department of Theoretical and Computational Biophysics, Max Planck Institute for Multidisciplinary Sciences
Bert L. de Groot: Department of Theoretical and Computational Biophysics, Max Planck Institute for Multidisciplinary Sciences
Loren B. Andreas: Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences
Stefan Becker: Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences
Christian Griesinger: Department of NMR-Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences
Gunnar F. Schröder: Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich

DOI: https://doi.org/10.1038/s41467-022-34552-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Interactions between α-synuclein fibrils and lipids have been associated with the development of Parkinson’s disease. This cryo-EM study reveals structural details of these interactions and suggests a mechanism for fibril-induced lipid extraction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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