Animal Models of Chorioamnionitis: Considerations for Translational Medicine
Tiphaine Raia-Barjat,
Margaux Digonnet,
Antoine Giraud,
Taghreed Ayash,
Seline Vancolen,
Mohamed Benharouga,
Céline Chauleur,
Nadia Alfaidy,
Guillaume Sébire
Affiliations
Tiphaine Raia-Barjat
Department of Gynaecology and Obstetrics, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France
Margaux Digonnet
Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France
Antoine Giraud
SAnté Ingénierie BIOlogie Saint-Étienne SAINBIOSE, DVH, INSERM U1059, Jean Monnet University, 42000 Saint-Etienne, France
Taghreed Ayash
Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Seline Vancolen
Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Mohamed Benharouga
Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France
Céline Chauleur
Department of Gynaecology and Obstetrics, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France
Nadia Alfaidy
Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France
Guillaume Sébire
Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspring. Unfortunately, chorioamnionitis is still missing effective biomarkers and early placento- as well as feto-protective and curative treatments. This review summarizes recent advances in the understanding of the underlying mechanisms of chorioamnionitis and subsequent impacts on the pregnancy outcome, both during and beyond gestation. This review also describes relevant and current animal models of chorioamnionitis used to decipher associated mechanisms and develop much needed therapies. Improved knowledge of the pathophysiological mechanisms underpinning chorioamnionitis based on preclinical models is a mandatory step to identify early in utero diagnostic biomarkers and design novel anti-inflammatory interventions to improve both maternal and fetal outcomes.
