Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy

Joyce Kim, MD; Tim Kaddis, MD; Spencer Boyle, MD; Sandeep Gupta, MD; Vivian Wang, MD; Joseph Yusin, MD

Journal of Allergy and Clinical Immunology: Global (Feb 2025)

Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy

Joyce Kim, MD,
Tim Kaddis, MD,
Spencer Boyle, MD,
Sandeep Gupta, MD,
Vivian Wang, MD,
Joseph Yusin, MD

Affiliations

Joyce Kim, MD: Department of Medicine, University of California Los Angeles, Los Angeles, Calif; Corresponding author: Joyce Kim, MD, Department of Medicine, University of California Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095.
Tim Kaddis, MD: Division of Allergy and Immunology, Greater Los Angeles VA Medical Center, Los Angeles, Calif
Spencer Boyle, MD: Division of Allergy and Immunology, Greater Los Angeles VA Medical Center, Los Angeles, Calif
Sandeep Gupta, MD: Division of Allergy and Immunology, Baylor Scott & White Medical Center – Plano, Plano, Tex
Vivian Wang, MD: Division of Allergy and Immunology, Greater Los Angeles VA Medical Center, Los Angeles, Calif
Joseph Yusin, MD: Division of Allergy and Immunology, Greater Los Angeles VA Medical Center, Los Angeles, Calif

Journal volume & issue: Vol. 4, no. 1
p. 100375

Abstract

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A rare injection site reaction known as Nicolau syndrome can occur in patients receiving subcutaneous immunotherapy. This syndrome has been reported only a handful of times in the literature related to subcutaneous immunotherapy.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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Abstract

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