A microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission

Shailabh Kumar; Felix J. H. Hol; Sujit Pujhari; Clayton Ellington; Haripriya Vaidehi Narayanan; Hongquan Li; Jason L. Rasgon; Manu Prakash

doi:10.1038/s41467-021-26300-0

Nature Communications (Oct 2021)

A microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission

Shailabh Kumar,
Felix J. H. Hol,
Sujit Pujhari,
Clayton Ellington,
Haripriya Vaidehi Narayanan,
Hongquan Li,
Jason L. Rasgon,
Manu Prakash

Affiliations

Shailabh Kumar: Department of Bioengineering, Stanford University
Felix J. H. Hol: Department of Bioengineering, Stanford University
Sujit Pujhari: Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of The Life Sciences, The Pennsylvania State University
Clayton Ellington: Department of Bioengineering, Stanford University
Haripriya Vaidehi Narayanan: Department of Bioengineering, Stanford University
Hongquan Li: Department of Electrical Engineering, Stanford University
Jason L. Rasgon: Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of The Life Sciences, The Pennsylvania State University
Manu Prakash: Department of Bioengineering, Stanford University

DOI: https://doi.org/10.1038/s41467-021-26300-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

High-throughput molecular surveillance of mosquitoes carrying dangerous pathogens is currently challenging. Here the authors present Vectorchip, a low-cost microfluidic platform enabling multiplexed detection of mosquito DNA, viral RNA and infectious viral particles at single bite resolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal