Analysis of Pharmaceutical Excipient MCC Avicel PH102 Using Compaction Equations

Peciar Peter; Eckert Maroš; Fekete Roman; Hrnčiar Viliam

doi:10.1515/scjme-2016-0012

Journal of Mechanical Engineering (Jul 2016)

Analysis of Pharmaceutical Excipient MCC Avicel PH102 Using Compaction Equations

Peciar Peter,
Eckert Maroš,
Fekete Roman,
Hrnčiar Viliam

Affiliations

Peciar Peter: Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Process Engineering, Nám. Slobody 17, 812 31 Bratislava, Slovakia
Eckert Maroš: Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Process Engineering, Nám. Slobody 17, 812 31 Bratislava, Slovakia
Fekete Roman: Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Process Engineering, Nám. Slobody 17, 812 31 Bratislava, Slovakia
Hrnčiar Viliam: Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Technologies and Materials, Pionierska 15,831 02 Bratislava, Slovakia

DOI: https://doi.org/10.1515/scjme-2016-0012
Journal volume & issue: Vol. 66, no. 1
pp. 65 – 82

Abstract

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This paper focuses on the characterization of the tabletting process and analysis one of the most common pharmaceutical excipients MCC Avicel PH102 by Heckel, Kawakita, Cooper-Eaton and Adams compaction equations. Experimental material was determined by measuring its parameters as particle size distribution, angle of wall friction and flow properties and for more detailed characteristics of the material particles, microscopy images of the powder before and after compressing were created.

Published in Journal of Mechanical Engineering

ISSN: 2450-5471 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Technology: Engineering (General). Civil engineering (General)
Website: https://sciendo.com/journal/SCJME

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