Frontiers in Cellular and Infection Microbiology (Jun 2022)

Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women

  • Yichan Zhang,
  • Yichan Zhang,
  • Xiaolin Xu,
  • Xiaolin Xu,
  • Liqun Yu,
  • Xingxian Shi,
  • Min Min,
  • Lijuan Xiong,
  • Jia Pan,
  • Yong Zhang,
  • Peipei Liu,
  • Guizhen Wu,
  • Guolan Gao,
  • Guolan Gao

DOI
https://doi.org/10.3389/fcimb.2022.814668
Journal volume & issue
Vol. 12

Abstract

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Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data.

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