Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова (Jun 2014)

VKORC1 gene -1639 G/A and 1173 C/Т polymorphisms in Nenets autonomous district indigenous population

  • P. A. Lavrinov,
  • N. I. Belova,
  • N. A. Vorobyeva

DOI
https://doi.org/10.24884/1607-4181-2014-21-2-33-36
Journal volume & issue
Vol. 21, no. 2
pp. 33 – 36

Abstract

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According to the data obtained the VKORC1 gene polymorphism prevalence in the native population of the Nenets autonomous region differed significantly from that in the Arkhangelsk population. The homozygous form of 1173T allele prevailed in the nenets. This may be protective against thrombosis but it increases the risk of artery calcification and of indirect overdosing of anticoagulants.

Keywords